International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 8, Issue:4, April, 2019

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(4): 229-236

Role of NS1 Antigen in Early Detection of Dengue during Epidemics
V.R. Vidhya* and N. Palaniappan
Sree Mookambika Instiute of Medical Sciences, Kulasekaram, Kanyakumari District, India
*Corresponding author

Dengue has become a major international public health problem due to human morbidity and mortality it causes. Dengue NS1 antigen has been detected in the serum of DEN virus infected patients as early as one day of onset of symptoms. In this study the potential use of dengue NS1 antigen and in early dengue diagnosis has been analysed. The study group consists of all febrile patients with fever of duration less than 5 days attending the medical OPD for a period of one year from July 2013. The blood sample was subjected to an immunochromatographic test for NS1 antigen, IgM and IgG antibodies. This was followed by ELISA for NS1 antigen, IgM and IgG antibodies. Out of 176 samples tested, 57 (32%) were positive for NS1 antigen by immunochromatographic test. The 57 samples which were found to be positive by NS1 ELISA were also found to be positive by immunochromatographic test. NS1 antigen detection is a useful tool in the early diagnosis of dengue infection and deserves inclusion in the diagnostic algorithm for suspected dengue fever cases. The results of NS1 antigen immunochromatographic test are comparable to that of NS1 antigen ELISA.

Keywords: Dengue, Aedes aegypti NS1 Antigen

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How to cite this article:

Vidhya, V.R. and Palaniappan, N. 2019. Role of NS1 Antigen in Early Detection of Dengue during Epidemics.Int.J.Curr.Microbiol.App.Sci. 8(4): 229-236. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.