National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present study investigated the participation of an inactive and active Src-kinase in the functions of cytoskeleton and pigment formation inHep2 cells. For increase of the inactive portion of the Src-kinase and decrease of its active part we entered specific Src-kinase family inhibitor CGP 77675 into cell population. For the decrease of the inactive portion of Src-kinase, the tumor cells were affected by ultraviolet (UV) radiation within 5, 30 and 60 minutes. We studied the dynamics of the quantity of cells with processes and also the cells with tyrosinase activity. It appeared that only the inactive Src-kinase participates in cytoskeleton formation and in tyrosinase activization. Strengthening of melanogenesis during long UV-radiation within 30 and 60 minutes reduced the portion of the inactive Src-kinase due to the intensification of tyrosinase synthesis. The last in turn began to compete with a cytoskeleton for the inactive Src-kinase that reduced a differentiation of cells and sharply worsened a phenotype of tumor cells.
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