National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Chronic hepatitis C infection is considered now a multi-system disease, affecting nearly all body system. Hepatic affection of such viruses are widely evaluated while extra-hepatic manifestations (including lungs)still need more studies, especially in children and adolescents . To evaluate if chronic HCV (CHCV) infection without treatment is associated with progressive deterioration of pulmonary functions. Fifty adolescent patients with CHCV infection (12-18 years) and 50 control health subjects included in the study, with full hepatic evaluation beside pulmonary function tests (PFTs) at the start of the study. PFTs were repeated in patient group after 6 and 12 months and evaluated in comparison to start results and to control group. There was a gradual deterioration of PFT in adolescent patients with CHCV infection reached a significant levels(FEV1 89 ± 1.3,FVC 88 ± 0.8, FEV1/FVC 91 ± 1.1) when compared to healthy control group(FEV1 96 ± 1.9,FVC 95 ± 1.2, FEV1/FVC 97 ±1.1 )with P value (0.02,0.03,0.01)respectively. Progressive decline in pulmonary functions is observed in adolescents with chronic HCV infection, but more researches are needed to further explore such deteriorations.
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