National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Infection is still noted to be one of the major complications in the treatment of fractures. Infections are associated with prolonged hospital stay, leading to higher treatment cost, morbidity and mortality, particularly when the infecting agents are multidrug resistant. To compare incidence of infective agents and their resistance pattern between post-operative closed and open fracture wounds. In this particular study 125 patients of all age group were enrolled with exclusion of patients with history of diabetes mellitus, chronic steroid therapy, chemotherapy and HIV positive patients. Patients were divided into closed fracture and open fracture patients. A total of 120 isolates were obtained from 110 patients. 15 patients were cultured sterile. Organisms obtained were Enterobacter spp. (19.17%), Klebsiella spp. (15.83%), Staphylococcus aureus (12.5%), Coagulase negative Staphylococcus spp. (11.67%), E. coli (10.83%), Pseudomonas (10.83%), Acinetobacter spp. (7.50%), Citrobacter spp. (5.0%), Burkholderia cepacia complex (2.5%), Aeromonas hydrophila (2.5%), Proteus mirabilis (0.83%) and Aerococcus viridans (0.83%). 100% isolates of Staphylococcus species were sensitive against vancomycin, followed by linezolid, gentamicin, tetracycline, ciprofloxacin and azithromycin. Ampicillin, amox-clav and ceftriaxone were most ineffective drugs. Enterobacteriaceae isolates were almost totally resistant against ampicillin followed by amoxy-clav. Levofloxacin and imipenem were found most effective antibiotics. Non-enterobacteriaceae gram negative strains were multidrug resistant, ciprofloxacin, levofloxacin and imipenem were found effective in 50-63% patients. In our study there was no significant difference of antibiotic sensitivity pattern was noted between post-operative closed and open fracture wounds.
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