International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 8, Issue:2, February, 2019

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(2): 2145-2152

Serodiagnosis of Scrub Typhus cases by Different Diagnostic Tests
Kalpana Mund1, Dipti Pattnaik1*, Shubhransu Patro2, J. Jena1, N. Singh1 and P. Mishra1
1Department of Microbiology2Department of Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar-751024, Odisha, India
*Corresponding author

Scrub typhus has been one of the most emerging and re-emerging rickettsial infections with increasing trend in incidences of disease worldwide including India. Clinical diagnosis of scrub typhus is difficult because the signs and symptoms of scrub typhus are almost like other febrile diseases. The mainstay in scrub-typhus diagnosis is serology. In developing countries, among the various laboratory tests to diagnose scrub typhus, Weil-Felix test is usually performed despite its low sensitivity. The current study was conducted to compare the efficacy of different serological methods for diagnosis of Scrub typhus. Weil-Felix test, IgM ELISA and ICT were performed in clinically suspected cases of scrub typhus using commercially available kits taking the conventional InBios Scrub Typhus Detect IgM ELISA as reference. Positive Predictive value, Negative Predictive Values, Percentage Sensitivity and Specificity for ICT and Weil-Felix is 100%, 98.52%, 97.23%, 100%, and 59%, 68.71%, 23.52, 91.22% respectively. A total of 253 samples were positive in reference standard InBios IgM ELISA. Owing to the constrains of the Weil-Felix test and IFA, commercially available recombinant IgM ELISA and ICT which has a good sensitivity and specificity may be an alternative in laboratories with moderate set up.

Keywords: Pyrexia, Scrub typhus, IgM ELISA, Weil-Felix test, ICT

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How to cite this article:

Kalpana Mund, Dipti Pattnaik, Shubhransu Patro, J. Jena, N. Singh and Mishra, P. 2019. Serodiagnosis of Scrub Typhus cases by Different Diagnostic Tests.Int.J.Curr.Microbiol.App.Sci. 8(2): 2145-2152. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.