International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:12, December, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(12): 321-332

Synthesis, Characterization and Biological Evaluation of Penicillin Derivatives Complexes with Some Transition Metal Ions
Ammar J. Alabdali and Yasser H. Sabah* 
Department of Chemistry, College of Sciences, Al-Nahrain University, Baghdad, Iraq
*Corresponding author

This study is for the purpose of academic knowledge to know the behavior of some ligands with some metal ions according to the ligands properties as bifunctional antibacterial (two β-lactams groups) and multidentate linkage; that the two new ligands have been prepared from the interaction of bifunctional aldehyde (terephthaldehyde and glyoxal) with the antibacterial 6-amino penicillanic acid (6-APA) to yield L1 and L2 respectively. The bifunctional bidendate-ligands L1 and L2 interacted with Co(II),Cu(II) and Zn(II) ions under reflux to prepare six new non-electrolytic complexes with mole ratio 2:1 M:L and general formula [M2L1ClX (H2O)Y].ZH2O (x,y, z) : natural number. The resulting products were characterized using 1H-NMR, Uv-Vis and  IR-spectroscopy. Metal and elemental analysis was performed along with molar conductivity and thermal analysis. The results suggested that the complexes could be with distorted octahedral geometry. The microbiological activity of the synthesized compounds have been evaluated in minimum inhibitory concentration (MIC) of the raw material 6-APA as a lead which was 10-3M, thus the derivatives were expected to be more active and sensitive against both Gram-positive and Gram-negative organisms at the selected concentration (10-3M).

Keywords: Schiff base,6-amino penicillanic acid,Terephthaldehyde,Glyoxal,Metal complexes.

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How to cite this article:

Ammar J. Alabdali and Yasser H. Sabah. 2016. Synthesis, Characterization and Biological Evaluation of Penicillin Derivatives Complexes with Some Transition Metal Ions.Int.J.Curr.Microbiol.App.Sci. 5(12): 321-332. doi:
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