Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
Home Editorial Board Current Issue Special Issue Archives Indexing Submit Article
Instruction to Authors Manuscript Charges Copyright Form Model Manuscript Process Flow (Time Frame) FAQ
Reviewer Guidelines Selection of Reviewers Join our Team of Reviewers Apply as Reviewer Reviewer Login
Editorial Review Policy Embargo Policy Ethical Expectations Consent For Identifying Information Informed Consent Manuscript Withdrawal Policy Peer Review Process Plagiarism Policy Ethical Violations Appeal Policy Against Editorial Decision Advertising Policies Authorship Policy
Access Policies Authorship Publication Policy Publication Ethics Complaints Policy Confidential Information Conflicts of Interest Policy Consent for Copyrighted Material Copyright Policy Corrections and Retractions Digital Preservation Policy Research On Human And Animal Studies Open Access Policy
Publication Ethics Contact
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2022 - IJCMAS--ICV 2022: 95.28 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020] For more details click here

Join as a Reviewer

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here
ICV 2022: 95.28
Index Copernicus ICI Journals Master List 2022 - IJCMAS--ICV 2022: 95.28
For more details click here
Announcement

See Guidelines to Authors
Current Issues
Download Publication Certificate

Original Research Articles                      Volume : 5, Issue:12, December, 2016
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38
Metrics and citations

Int.J.Curr.Microbiol.App.Sci.2016.5(12): 234-239
DOI: http://dx.doi.org/10.20546/ijcmas.2016.512.025


Effects of Esteradiol and Testosterone on Tissue Antioxidant Status and Susceptibility to Subdiabetogenic Dose of Alloxan in Male Rats
Sadiq M.A. AL-Hiti*
College of Pharmacy, Department of Pharmacology and Toxicology, Baghdad University, Iraq
*Corresponding author
Abstract:

This study was designed to investigate the influence of estradiol and testosterone on the major tissues antioxidant, glutathione (GSH), and the lipid peroxidation product, malondialdehyde (MDA) in various tissues of gonadectomized rats. Also, the susceptibility of sex hormones pretreated rats to the subdiabetogenic dose of alloxan (Alx) were also studied. Castration was associated only with elevation of pancreatic GSH content compared to controls. Testosterone treatment normalized pancreatic GSH content, but decreased those of kidney and liver. Also it elevated MDA levels in almost all studied tissues. Interestingly, pretreatment of male rats with testosterone (but not estradiol) increased the susceptibility of rats to the subdiabetogenic dose of ALX, as manifested by glucosurea and mild hyperglycemia. Control rats failed to respond to ALX.


Keywords: Estradiol, Testosterone, Antioxidant, Glutathione, Malondialdehyde, Alloxan and antidiabetogenic.

Download this article as Download

How to cite this article:

Sadiq M.A. AL-Hiti. 2016. Effects of Esteradiol and Testosterone on Tissue Antioxidant Status and Susceptibility to Subdiabetogenic Dose of Alloxan in Male Rats.Int.J.Curr.Microbiol.App.Sci. 5(12): 234-239. doi: http://dx.doi.org/10.20546/ijcmas.2016.512.025
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

Citations
Home | Terms of Use | Copyright Form 2012-2020 Copy rights reserved IJCMAS. Powered by ThinkNEXT Technologies