International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:12, December, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(12): 11-17

Assessment of Serum Interleukin-33 Level in Psoriatic Patients
Abdel Aziz I. El-Taweel1, Fatma M. El-Sawy1, Omaima A. El Sayed2*
and Nessma G.Z. Amin1
1Dermatology and Andrology, Faculty of Medicine, Benha University, Egypt
2Microbiology and Immunology Department, Mansoura University, Egypt
*Corresponding author

Psoriasis is a common chronic inflammatory skin disease affecting up to 2–3% of the population worldwide. Interleukin-33 is a recently discovered cytokine and one of the newest members that belongs to the IL-1 super-family inflammatory cytokines and is mainly expressed by different types of structural cells. IL-33 is considered an alarm molecule due to its release after necrosis or tissue damage.  Psoriasis is associated with chronic inflammation and it often coexists with inflammatory arthritis in which IL-33 has been implicated. Assessment of serum IL-33 levels in psoriatic patients of different types and invistigate its correlation to the severity and extent of psoriasis.It is a case-control study, serum IL-33 levels were assessed by using commercial enzyme-linked immunosorbent assay kits (ELISA) in 40 psoriatic patients of different types (group I) and 30 apparaently healthy subjects as control (group II) with matched age and sex. A significant difference in IL-33 serum levels between patients and control was detected. Also positive correlation between IL-33 and Psoraisis Area and Sevirity Index (PASI) was detected. IL-33 could be considered as a reliable marker among different types of psoriasis and disease severity.

Keywords: Psoriasis,enzyme-linked immunosorbent assay, interleukin 33.

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How to cite this article:

Abdel Aziz I. El-Taweel, Fatma M. El-Sawy, Omaima A. El Sayed and Nessma G.Z. Amin. 2016. Assessment of Serum Interleukin-33 Level in Psoriatic Patients.Int.J.Curr.Microbiol.App.Sci. 5(12): 11-17. doi:
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