Rheumatoid arthritis is a common systemic inflammatory disease and the diagnosis is primarily based on clinical manifestations. This study was conducted with the aim of comparison between rheumatoid factor (RF) and anti-ccp antibody tests for the diagnosis of Rheumatoid Arthritis. A total of 312 samples comprising 124 (39.7%) from Rheumatoid arthritis patients and 188 (60.3%) from non-Rheumatoid arthritis patients, were collected. Anti-ccp test was found to be better than Rheumatoid factor in sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), Likelihood Ratio Positive, Likelihood Ratio Negative, False Positive Rate, False Negative Rate.

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