Urinary tract Infection (UTI) is among the most common infections described in
outpatient setting and hospital patients. Klebsiella species isolated from urine
samples from Gangasaras Diagnostic and Research Centre, Pattukkottai, Tamilnadu, were studied to determine the antimicrobial susceptibility pattern. Between January 2012 and December 2012, a total of 2400 specimens processed in
the laboratory, of which 72 (11.2%) yielded Klebsiella species, from outpatients and inpatients. Organisms were identified by conventional methods. Klebsilla
species were isolated mostly from female urine specimens. Antimicrobial susceptibility was done by the disk diffusion methods. The antimicrobial disk used
include: amoxicillin, ampicillin, cefotaxime, ceftazidime, ceftriaxone, cephalexin, ciprofloxacin, nalidixic acid, norfloxacin, ofloxacin, amikacin, gentamicin, tobramycin, imipenem, nitrofurantoin, and cotrimoxazole. All were Himedia products. Antimicrobial susceptibility to various group drugs used was generally
poor. The most sensitive antimicrobial was amikacin and imipenem with 62
(86.1%) isolates susceptible to it, followed by gentamicin and tobramycin with 58
(80.6%), ofloxacin with 57 (79.2%), ciprofloxacin with 55 (76.4%). 30 (41.7%)
isolates were multiresistant to all the antimicrobial agents used. The result of this
study will help in the empiric therapy of infection caused by Klebsiella species in Tamil Nadu State, but continuous surverillance of antimicrobial resistance of the organism is very necessary in the formulation of a sound antibiotic policy in the hospital. |