International Journal of Current Microbiology and Applied Sciences |
ISSN: 2319-7706 Volume 2 Number 8 (2013) pp. 286-295 |
Immunomodulatory activity of Phallusia nigra Savigny, 1816 against S-180 |
V.K.Meenakshi*, M. Paripooranaselvi, S. Sankaravadivoo, S. Gomathy and K.P. Chamundeeswari |
Department of Zoology, A.P.C.Mahalaxmi College for Women, Tuticorin, Tamilnadu, India *Corresponding author e-mail: vkm.apcm@yahoo.co.in |
A B S T R A C T |
Immunomodulatory activity of ethanolic extract of simple ascidian Phallusia nigra was determined against sarcoma 180 (S-180) cells. For 0.60 mg/ml concentration, 100% toxicity was observed. The extract administration at 50, 100 150 and
standard drug Vincristin at 80 mg/kg body weight to different groups showed
significant reduction in weight of body. The relative organ weight did not register any significant change. The results indicated that extract inhibited tumor growth by
52.69% compared to 47.12% in the standard drug treated group. The extract also
significantly increased immune functions by increasing quantitative hemolysis of sheep RBC, lymphocyte proliferation, NK cytotoxicity and phagocytosis rate. The
immunomodulatory effect was dose dependent. It is suggested that bioactive
compounds present in Phallusia nigra modulates immune functions and hence may
play a vital role in cancer prevention and treatment. |
Keywords |
Phallusia nigra;
immuno- modulatory; Cytotoxicity; antitumoral; S-180. |