International Journal of Current Microbiology and Applied Sciences
ISSN: 2319-7706 Volume 2 Number 6 (2013) pp. 30-40
Evaluation of Cytogenetic Effects of β-Cyfluthrin in Swiss Albino Mice
Rajbala Verma, Kumud Kant Awasthi, Inderpal Soni* and P.J. John
Environmental Toxicology Laboratory, Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur - 302004, India *Corresponding author e-mail:;
The aim of present investigation was to evaluate -cyfluthrin induced oxidative stress and genotoxicity in male Swiss albino mice. Two doses of pesticide viz. 1/20 of LD50 (Low dose) and 1/10 of LD50 (High dose) were administered for 7 and 14 days to different groups of mice. Activity of antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD) were estimated in the liver. Genotoxicity of pesticide was assessed in bone marrow cells of mice using chromosomal aberration assay. Cyclophosphamide was used as positive control. -cyfluthrin reduced the body weight and food consumption in treated animals. CAT and SOD activities were not affected in 7 days group but these were significantly reduced in 14 days group. Mitotic index decreased in a days as well as dose dependent manner. A significant number of chromosomal aberrations like acentric fragements, chromosome breaks, centric rings and polyploidy occurred in 14 days groups. It may therefore be inferred that -cyfluthrin has the ability to elicit oxidative stress and cause genotoxicity in mice at the tested dose levels
β-cyfluthrin, genotoxicity, chromosomal aberration assay, mitotic index, oxidative stress.