International Journal of Current Microbiology and Applied Sciences
ISSN: 2319-7706 Volume 2 Number 10 (2013) pp. 537-559
DPPH Free Radical Scavenging Activity of the Extracts of the Aquatic Fern
Marsilea quadrifolia Linn
N.Senthil1, P.M.Balu1* and K. Murugesan2
1Department of Biochemistry, Kanchi Shri Krishna College of Arts and Science, Kilambi, Krishnapuram, Kancheepuram, Tamil Nadu, India. 2Professor, Centre for Advanced studies in Botany, University of Madras, Chennai, Tamil Nadu, India.
The result of the present study showed that, spirulina and insulin brings back the blood glucose to normal in diabetes-induced rats. After treatment, in the pancreas no insulitis was observed. From the above results it is shown that the treatment materials used has hypoglycemic activity. Hypoglycemic action of the herbal plant (Morinda citrifolia) in diabetic rats may be because of thiobarbituric cid reactive substance (TBARS) and hydroperoxides, which have antioxidant potential, which in turn may be responsible for the hypoglycemic potential. Hypoglycemic action of spirulina is due to the decrease in the activity of hexokinase in liver and increase in glucose 6 phosphatase activity in muscles and the hypoglycemic activity of insulin may be due to the decrease in intestinal glucose absorption, decrease of hepatic glucose production and increase of peripheral glucose disposal. So the experimental evidence obtained from this study indicates that, spirulina and insulin possess hypoglycemic property but has got more hypoglycemic effect than spirulina and insulin, which is standard drug, used for diabetes treatment. The hypoglycemic activity is also confirmed by histopathological examination of pancreas.
Morinda citrifolia; thiobarbituric cid reactive substance; hypoglycemic effect