| International Journal of Current Microbiology and Applied Sciences |
| ISSN: 2319-7706 Volume 2 Number 10 (2013) pp. 369-381 |
| A Prospective Clinical Evaluation between Intra - Articular Injections of Methyl Prednisolone and Triamcinolone in Osteoarthritis of Knee Based On the Efficacy, Duration and Safety |
| Shikhar1 , Jitendra Kumar Pandey2 , Akanksha Narayan 3 and Dr. Ramneek Mahajan4 |
| 1Department Of Orthopaedics, Nova Speciality Surgery, Kailash Colony, New Delhi and Hindu Rao Hospital, New Delhi, India 2Department of microbiology, MGM Institute of Health Sciences, Navi Mumbai, India 3Cliniminds Institute of health Sciences & training Management, New Delhi, India 4Head, Orthopaedics & Joint Replacement, Nova Specialty Surgery, Kailash Colony New Delhi-110048 |
| ABSTRACT |
| Osteoarthritis (OA) is a heterogeneous group of conditions that lead to joint symptoms which are associated with defective integrity of articular cartilage, in addition to related changes in the underlying bone at the joint margins. OA is the most common joint disease of humans both in the western world as well as in India. Age, Major joint trauma and repetitive joint use (Anterior cruciate ligament insufficiency or meniscus damage and meniscectomy) obesity, genetic differences have been found as risk factors for development of OA. Intra-articular corticosteroids are widely used in the management of arthritic conditions for giving short term symptomatic relief from pain and stiffness. This study aimed to compare the efficacy of two intraarticular corticosteroid injections (Methylprednisolone and Triamcinolone) for providing symptomatic pain relief and improving the functional state and quality of life of the patients having osteoarthritis of knee. Long-term treatment of knee OA with repeated steroid injections at reasonable intervals appears to be clinically effective for the relief of symptoms of the disease. In the view of statistical data, we consider that Methylprednisolone may be first choice if early considerable symptomatic improvement is required. The results of the study can be extrapolated on patients who are co-operative and suffer from moderate to severe diseases. |
| Keywords |
| Osteoarthritis; knee; degenerative joint disease; symptomatic pain relief; VAS scale; WOMAC score; SF-36 form; Methylprednis olone; Triamcinolone |