International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 7, Issue:9, September, 2018

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(9): 736-744

Importance of Immunoglobulin M in Detecting Cases of Measles in Children with Clinically Suspected Measles
Hajira Osmani and K. Nagamani
Department of Microbiology, Gandhi Medical College and Hospital, Secunderabad, Hyderabad, Telangana state, India
*Corresponding author

Measles, an acute viral illness caused by a virus belonging to the family Paramyxoviridae, is a vaccine-preventable disease. Children’s between 9 months and 12 years of age are mostly affected and presents with fever and maculopapularrash. Despite the national immunization program, measles virus infection is common in India. Objectives of the study are 1. To study the suspected cases of measles virus infection with high fever and characteristic rashes, among children. 2. To detect antibody levels against measles virus by ELISA IgM and IgG. A total of 49 suspected measles cases between 9 months to 12 years of age of both sexes were included in the study and blood samples were collected after informed consent. The serum samples were screened for Measles IgM and IgG (Cal Biotech) ELISA test. The sensitivity and specificity of the test is 97%. The time taken for the test is 1 day. The test was carried out keeping in view the instructions of the manufacturer. Out of 49 cases, 25 (51%) of the patient studied were male and 24 (48.9) were female. The samples were screened for measles virus specific IgM and IgG.100% (49) positivity were observed in Measles virus specific IgM ELISA, whereas only 42.8% (21) positivity were observed for measles virus specific IgG in both the groups for Measles virus infection. Immediate results of IgM and IgG will help the patient in early diagnosis and also to the clinicians for patient management.

Keywords: Immunoglobulin M, Measles, IgM & IgG

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How to cite this article:

Hajira Osmani and Nagamani, K. 2018. Importance of Immunoglobulin M in Detecting Cases of Measles in Children with Clinically Suspected Measles.Int.J.Curr.Microbiol.App.Sci. 7(9): 736-744. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.