International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 7, Issue:9, September, 2018

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(9): 569-582

Exploration of Molecular/Antigenic Mimicry between Trichuris ovis and Its Ovine Host
Mamoni Das, Madhurendra Bachan, Ruma Jas*, Soumitra Pandit and Surajit Baidya
Department of Veterinary Parasitology, West Bengal University of Animal and Fishery Sciences, 37, Kshudiram Bose Sarani, Kolkata – 700 037, West Bengal, India
*Corresponding author

Trichuris ovis is one of the prevalent and non-pathogenic nematode of sheep. The whole anterior part of T. ovis remains embedded in the caecal mucosa of sheep with any marked inflammatory reaction. Helminth parasites evade host immune response by acquiring some host proteins or by mimicry of host antigens. The present study was conducted to explore any molecular mimicry between the T. ovis and sheep. Crude somatic antigen of anterior and posterior part of male and female and excretory-secretory antigen of T. ovis and the caecal mucosal antigen of sheep (CSAg-Ms) were prepared and antigenic characterization was done by SDS-PAGE and subsequently by western blot analysis with a view to detect any shared as well as cross-reactive antigens between T. ovis and CSAg-Ms. Five antigenic peptides (57, 51, 31, 21 and 14 kDa) were common among the antigens of T. ovis and caecal mucosal antigen of sheep. Five immunogenic peptides (75.6, 55, 47, 37.8 and 24 kDa) of T. ovis showed cross-reactivity with the hyperimmune sera against CSAg-Ms raised in rabbits. Therefore the comparatively non-pathogenicity of T. ovis in sheep might be due to the presence of antigenic mimicry as well as cross-reactive antigens between T. ovis and its host.

Keywords: Antigens, Mimicry, Trichuris ovis, Sheep

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How to cite this article:

Mamoni Das, Madhurendra Bachan, Ruma Jas, Soumitra Pandit and Surajit Baidya. 2018. Exploration of Molecular/Antigenic Mimicry between Trichuris ovis and Its Ovine Host.Int.J.Curr.Microbiol.App.Sci. 7(9): 569-582. doi:
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