National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The study was conducted in cases of RFM presented within 12 to 24 hours after parturition to Obstetrics Unit of Madras Veterinary College, Chennai. Group I received placebo treatment with one litre of normal saline intravenously. Group II cows, treated with intrauterine proteolytic bolus containing nitrofurazone, metronidazole and urea and antibiotic therapy (Inj. Streptopenicillin @ 20,000 units/kg body weight) without manual removal for 7 days. Groups III cows, received single dose of 2, 00,000 CDU of collagenase plus 40 mg of calcium chloride and 40 mg of sodium bicarbonate dissolved in one litre of normal saline at a pH of 7.5 intravenously through jugular vein (Eiler and Hopkins,1993). Group IV received single dose of 2, 00,000 U of collagenase intravenously. The endometrial histopathology findings on day 14 and 35 in group I revealed mild to moderate glandular activity with haemorrhage and vascular activity, hyperplasic changes in the mucosa and infiltration of mononuclear cells. The higher degree of focal necrosis of epithelial mucosa and infiltration of neutrophils were recorded in group II and IV than group I and III; group II had severe fibrotic necrosis than group IV. Group II had severe diffused cellular infiltration and increased inflammatory response. Group III had mild to moderate glandular activity, infiltration of bacterial colonies, mild necrotic tissues, neutrophilic and lymphocytic infiltration; group IV had higher leucocytic infiltration, bacterial load and focal necrosis than group III. These histopathological results were revealed that the administration of collagenase through intravenous route had achieved better healing and recovery.
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