Blood transfusion saves millions of people worldwide each year, but in developing countries like India, Transfusion Transmitted Infections (TTI’s) poses a great problem. With every unit of blood, there is 1% chance of transfusion-associated problems including transfusion-transmitted diseases. Viral infections cause the majority of morbidity and mortality in blood recipients. According to WHO estimate every year, due to lack of effective screening of blood donors results in up to 160,000 new cases of HIV, 16 million new infections with HBV, and 5 million new HCV infections. Therefore Screening of the blood donors is very essential in preventing Transfusion Transmitted Infections (TTI’s). Purpose: Study aims to know the prevalence of serological markers for HIV, HBV, HCV and Syphilis among the voluntary and replacement blood donors. Also To know the high risk age group among the blood donors infected with transfusion transmitted infections. A written n informed consent taken. All the blood samples collected from donors with sterile aseptic precautions. Screening blood samples for HIV, HBV, HCV done by ELISA and for Syphilis by RPR test. All the positive samples were retested by rapid Card method. Results: Out of total 14520 blood donors 12432(85.6%) were Voluntary donors and 2088 (14.4%) were replacement donors. A total of 212 samples found to be positive for Transmission transmitted Infections. Study demonstrated prevalence of HBV infections as 1.06%, followed by HIV as 0.2 %, HCV infections as 0.14% and Syphilis as 0.05%. Conclusion: The study demonstrated overall prevalence of Transfusion Transmitted Infections to be low i.e., 1.4%

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