This study demonstrated the antibiotic properties of aqueous and methanol extracts of Acalypha ciliata leaves. This was carried out using both gram-negative and gram-positive bacteria which included Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Salmonella typhi, Proteus mirabilis, Klebsiella pneumonia, and Streptococus pyrogenes. The aqueous extract of Acalypha ciliata leaves showed antibacterial activity ranging from 8.00 - 17.00±2.00mm, while that of methanol extract was from 9.00 - 20.00±4.00mm. The duration of antibacterial activity observed in aqueous extract ranged from 5.00 – 11.00± 2.00 days, while that of methanol extract ranged from 5.00 – 12.00±.00 days. The minimum inhibitory concentrations (MIC) of both methanol and aqueous extracts against the test bacteria were between 6.25 – 12.50±0.00mg/ml. However, the minimum bactericidal concentration (MBC) of both aqueous and methanol ranged from 9.38 – 25.00±0.00 mg/ml. The result of colony forming unit (CFU) showed that Klebsiella pnumoniae had the highest CFU value of 4.15 ±0.04 x 10⁸cfu/ml while Proteus mirabilis had the least CFU             of 1.27±0.06 x 10⁸cfu/ml. This research indicates that extracts of Acalypha ciliata leaves has broad spectrum antibacterial properties.

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