National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present study was conducted on 18 healthy dogs of either sex weighing between 10-20 kg to evaluate the effects on various haematological and biochemical profile using ketamine alone and in combination with dexmedetomidine or butorphanol in atropinized dogs. The experimental work was divided into three groups K (ketamine), DK (dexmedetomidine-ketamine) and BK (butorphanol-ketamine). Atropine sulphate @ 0.04 mg/ kg intramuscularly was administered 15 minutes prior to treatment in all the groups of animals. Haematological studies revealed non-significant changes in haemoglobin, Packed cell volume, Total erythrocyte count, Total leucocyte count and Differential leucocyte count at various time intervals after different treatments in group K, DK and BK. Serum glucose showed a significant (P<0.01) increase in all the groups initially which returned to base values by 24 hrs. Other biochemical parameters like serum total protein, serum urea nitrogen, creatinine and serum enzyme viz. AST and ALT values showed non-significant changes at various time intervals in all the three groups but was within normal physiological range. There were transient changes in haemato-biochemical profiles which were compensated and returned towards normalcy by 24 hrs in all the three groups. It was concluded that ketamine in combination with dexmedetomidine or butorphanol can be safely used as general anaesthetic in compromised and clinically healthy dogs.
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