National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Marbofloxacin is a third generation fluorinated quinolone, exclusively used in veterinary medicine. The dosage regimen of drugs can be optimized by their pharmacokinetic studies. Pharmacokinetics of marbofloxacin after repeated intravenous (i.v.) administration was not reported earlier in any veterinary species. Hence, present study was planned to investigate the pharmacokinetics of marbofloxacin following single (5 mg/kg) and repeated dose (5 mg/kg, for 5 days) i.v. administration in broiler chickens. Following i.v. administration of marbofloxacin, the mean values of elimination half-life (t1/2β) (single dose: 5.55 ± 0.67; repeated dose: 5.12 ± 0.25 h), volume of distribution at pseudo equilibrium Vd(area)(single dose:1.49 ± 0.12; repeated dose: 1.37 ± 0.08 L/kg) and area under curve (AUC) (single dose: 26.80 ± 2.08; repeated dose: 27.60 ± 2.57 µg.h/mL) were found in the present study. Significant difference in total body clearance (ClB) and mean residence time (MRT) were not observed after single or repeated dose i.v. administration. The mean ratio of K12 / K21 was significantly (p < 0.01) higher after repeated i.v. administration compare to single dose. The plasma drug concentration greater than 0.10 ± 0.02 and 0.15 ± 0.03 mg/mL (therapeutically effective concentration) were maintained up to 24 h after single and repeated drug administration, respectively. Marbofloxacin following single and repeated dose i.v. administration (5 mg/kg) showed favorable pharmacokinetic profiles in chickens.
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