National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present study was undertaken to study the EC50 of aqueous extract of Dolichos biflorus seeds against ethylene glycol induced renal stone in rats. Hyperoxaluria and Calcium oxalate deposition in the kidney was induced by oral administration of ethylene glycol (EG) and ammonium chloride in the drinking water to a final concentration of 0.75% and 2%, respectively for 28 days. The animals were divided into 5 groups, viz. healthy control, untreated control, 150, 250 and 300 mg test extract groups. Efficacy of treatment was assessed by estimating serum concentrations of urea nitrogen, Creatinine and histopathology. The serum urea nitrogen and serum creatinine was lower in extract treated rats than the untreated rat. Histopathology of kidney revealed lesions in the renal parenchyma of untreated rats and kidney lesions were almost absent in 300 mg/kg body weight dose. The aqueous extract of Dolichos biflorus seeds was found to be effective against renal stone in wistar rats. The EC50 of the extract was found to be 300mg/kg body weight.
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