National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
For more than ten years, there has been a scientific and journalistic controversy whether BPA causes adverse effects on human. Humans are routinely exposed to BPA, an estrogenic chemical present in food and beverage containers, dental composites, and many products in the home and workplace. In order to study the effects of BPA on the organ of pregnant rat brain, the albino rats were administrated to low& high concentrations of BPA (50 mg/kg. d & 500 mg/kg. d). We aimed to study the toxic effect of BPA on the body & brain weight, developmental structure of cerebellum in albino pregnant rat. After 8 days (Doses were administrated gestational day 8th to 15th), the antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and glutathione (GSH) concentrations in the organ was measured. Results showed that the MDA contents were increased with the added concentration of the BPA. But the SOD, CAT, GSH content was decreased. BPA induction also caused histopathological changes in the rat brain and cerebellum. All BPA treatment also revealed an increase in DNA fragmentation as evidenced by an increase in concentration of dose. It is indicated BPA can induce the rat’s oxidative damage and the effect is much easier for the brain.
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