National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The increasing resistance to many antimicrobial agents is seen in Staphylococcus aureus in all healthcare facilities. The commonest antibiotic for the treatment of the Methicillin and multi drug resistant Staphylococcal infections is clindamycin. Emergence of these resistances in Staphylococcus aureus has resulted in failure of clindamycin therapy. A total 220 Nasal swabs from healthy persons were collected and processed by standard microbiological procedures. Staphylococcus aureus was isolated in 48 cases (21.82 %) among which 6.25% were Methicillin resistance. All the Staphylococcus aureus isolates were sensitive to Amikacin, mupiriocin, teicoplanin, vancomycin and linezolid (100%). Ampicillin was the most resistant (54%) antibiotic followed by Erythromycin (40%), ciprofloxacin (33%), cotrimoxazole (31%), Ampicillin calvulanic acid (23%), clindamycin (17%) and chloramphenicol (15%), gentamycin (10%), levofloxacin (8%) and doxycycline (2%). Inducible clindamycin resistance among S. aureus isolates was 6.25%. The percentage of inducible clindamycin resistance was higher (66.67%) among MRSA compared to MSSA (2.23%). The D-test is a simple and effective tool for the phenotypic detection of inducible clindamycin resistance in S. aureus. It should be taking forward in routine practice for proper patient management and empirical therapy guideline.
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