National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Chymases belong to family of serine proteinases that are abundantly produced by mast cells in the blood vessels and the myocardium, Recent biochemical reports suggested that chymase is involved in a number of important physiological processes, such as inflammation, stimulation of sub mucosal gland secretion, processing of hormones and cytokines, release of growth factor, parasite expulsion and tissue remodeling. They show broad peptidolytic activity and are involved in a variety of functions. Chymase provides an important mechanism to maintain steady state AngII concentration in tissues but not in plasma. The review also gives information regarding various roles of chymase and its significance in heart modelling, chymase is a plays important role in inflammation and remodeling in the asthmatic lung. Chymase is the major chymotryptic proteinase of human mast cells, can be released in substantial quantities by mast cell activation,Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet . chymase as an important target for preventing complications of metabolic syndrome .Chymase plays a crucial role in angiotensin II formation in various tissues. Chymase converts angiotensin I to angiotensin II and it can also convert precursors of TGF-β and MMP-9 to their active forms.Chymase has various applications few are mentioned in this review.
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