National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Sepsis is a major problem in neonates. Clinical criteria alone could not establish the diagnosis of neonatal sepsis. It is extremely important to make an early diagnosis of neonatal sepsis for the prompt institution of anti-microbial therapy, which improves outcomes. The aim of this study is to determine the diagnostic performance of C - reactive protein (CRP) as early diagnostic marker in detection of neonatal sepsis in intensive neonatal care unit in comparison to that of blood culture and Hematological parameters like micro ESR and Total WBC count. This prospective study was conducted on neonates admitted to neonatal intensive care unit (NICU) at Tirunelveli Medical College Hospital, Tirunelveli, Tamil Nadu. Blood specimens (n = 60) were obtained from each neonate prior to commencement of antibiotics for sepsis work up including Hematological parameters like micro ESR, Total leukocyte count, absolute Neutrophil count (ANC), immature neutrophils to Total Neutrophil count ratio (I/T ratio). Blood culture was carried out by conventional method. Serum CRP level was measured by latex agglutination method. As per present study the sensitivity of CRP in predicting sepsis was 73.1 %, its specificity was 60%, its positive predictive value was 57.6 % and its negative predictive value was 77 %. P value of the test applied for statistical significance is less than 0.0001 which is statistically significant for CRP. Results of the current study indicate that despite the continuing emergence of newer markers of sepsis, CRP still plays a central role in the diagnosis of neonatal sepsis.
Citations |
 |
 |
 |
 |
