National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Coagulase-negative Staphylococci (CoNS) have emerged as predominant pathogens in hospital and community acquired infections. Clindamycin is a good therapeutic agent in treatment of skin, soft tissue as well as serious infections caused by both methicillin sensitive and resistant Staphylococci. However, strains with inducible clindamycin resistance often lead to therapeutic failure. Hence, each laboratory should be aware of the local prevalence of this resistance among clinical staphylococcal isolates. Therefore, the present study was done to evaluate the prevalence of inducible clindamycin resistance among CoNS isolates. A total of 152 CoNS isolated from clinical samples were evaluated for antimicrobial susceptibility testing using Kirby Bauer disk diffusion method and simultaneously D-zone test was interpreted by putting clindamycin and erythromycin disks adjacent to each other. Out of 152 CoNS isolates tested, 38.8% were methicillin resistant (MRCoNS) and 61.2% were methicillin sensitive (MSCoNS), with 33.6% hospital acquired strains and 66.4% community acquired strains. The prevalence of inducible clindamycin resistance was found to be 14.5%, with higher prevalence among MRCoNS (20.3%) as compared to MSCoNS (10.8%), also higher prevalence among community acquired (68.2%) as compared to hospital acquired strains (31.8%). All isolates with inducible resistance were 100% sensitive to vancomycin, linezolid and teicoplanin. To conclude, D-zone test should be performed routinely for appropriate prescription of clindamycin therapy for isolates with true clindamycin sensitivity only.
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