National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Nasal carriage of methicillin resistant Staphylococcus aureus (MRSA) is a key factor in the epidemiology and causation of infection. Health care workers, who are nasal carriers of MRSA, act as reservoirs of infection. This is an important risk factor in the development of nosocomial infections. Mupirocin is used to decolonise MRSA carriers. But with the widespread use of mupirocin, resistance to mupirocin has set in. This poses a challenge to the use of mupirocin against MRSA. This study was carried out to know the occurrence of high and low level mupirocin resistance in Staphylococcus aureus. Staphylococcus aureus isolated from the anterior nares of health care workers (HCWs) were identified using standard protocol. Methicillin resistance was identified using cefoxitin disc (30µg). High level and low level mupirocin resistance was identified using 5µg and 200µg mupirocin discs. The tests were done by Kirby Bauer disc diffusion method as per CLSI guidelines. SPSS Version 20 software was used to give percentage analysis of the data. Chi-square test was used for statistical analysis (p value <= 0.05 is taken as statistically significant). Of the 300 nasal swabs taken from HCWs, 28 Staphylococcus aureus were isolated, of which 24 isolates were MSSA and 4 isolates were MRSA. One MSSA (1/24, 4.1%) isolate showed high level mupirocin resistance. Only 1 MRSA isolate (1/4, 25%) had high level resistance to mupirocin. No low level resistance to mupirocin was detected in the MSSA and MRSA isolates. Presence of mupirocin resistance in Staphylococcus aureus isolates is a cause of grave concern. The hospital infection control activities and surveillance have to be stepped up, to identify and control mupirocin resistance.
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