National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Shankhpushpi is botanically termed as Evolvulus alsinoides; the extracts have exhibited antioxidant, anti-ulcer, and immunomodulatory activities. In addition, recently scientific research has disclosed adaptogenic and anti-amnesic properties. The main objective of the present work is to investigate the invitro therapeutic potential activities of methanolic extract of whole plant of Evolvulus alsinoides on albumin denaturation, membrane stabilization test and Proteinase, xanthine oxidase, lipoxygenase inhibitory activities Establishing Anti inflammatory properties, Inhibition of albumin denaturation showed Albumin denaturation in methanolic plant extract (500μg/ml) 82.32 ± 0.50 against standard Aspirin (100μg/ml) 68.40 ± 0.40. Membrane stabilization plant extracts: 65.70 ± 0.60 against standard Aspirin: 84.20±0.40. Xanthine oxidase IC50 (ðœ‡M) ± SEM, methanolic extract: 0.42 ±1.40 against standard Allopurinol: 0.20 ± 0.40. IC50 of Anti-lipoxygenase Activity (500μg/ml): 52.60 against standard Indomethacin (50μg/ml): 46.50%. The extract fractions serve as free radical inhibitors or scavenger or acting possibly as primary oxidants and inhibited the heat induced albumin denaturation, proteinase, lipoxygenase and xanthine oxidase (XO), which are agents that directly inhibit the synthesis of uric acid in vivo. Certain active constituents present in Evolvulus alsinoides plant extracts like flavonoids and polyphenolic compounds possess potent Anti inflammatory therapeutic responses.
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