National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Cancer is becoming a health problem in all over the world, searching for anticancer therapy from plants natural products has been one of the sustainers of cancer chemotherapy approximately for the past half a century. Chelidonium majus (Poppy Family) is a plant which is distributed in nature and has been used as a traditional medicine. The plant extract showed high content of alkaloids which revealed cytotoxic effect in a cell type and dose dependent way. Cytotoxic analysis of alkaloids extract from Chelidonium majus using MTT assay on different cell lines. 100 grams of the plant material powdered and extracted with methanol using Soxhlet installation, the extract was subjected farther more for acid-base extraction and purification with chloroform. Cytotoxic effect of total alkaloid was estimated using MTT-assay manufacturer’s instructions. The total alkaloid extract of C. majus exhibited remarkably significant cytotoxic effect on (Hep-G2, MCF-7 and A-549) cell lines in a dose dependent and cell type dependent manner. The extract illustrated considerable cytotoxic activity against various types of cancer cell lines in vitro. The antitumor activity was extremely efficient in a dose dependent manner it displayed decreased viability of tumor cells.
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