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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here
ICV 2022: 95.28
Index Copernicus ICI Journals Master List 2022 - IJCMAS--ICV 2022: 95.28
For more details click here
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Original Research Articles                      Volume : 7, Issue:1, January, 2018
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38
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Int.J.Curr.Microbiol.App.Sci.2018.7(1): 431-438
DOI: https://doi.org/10.20546/ijcmas.2018.701.050


In silico Identification of Inhibitors from Salacia reticulate Plant against Diabetic Target Protein
D. Ramakrishna, A.T. Shashank, S. Kiran, K.M. Kumar and G.A. Ravishankar*
Dr. C.D Sagar Centre for Life Sciences, Biotechnology Department, Dayananda Sagar College of Engineering, Dayananda Sagar Institutions, Kumaraswamy Layout, Bengaluru 560 078, Karnataka, India
*Corresponding author
Abstract:

Salacia species for its antdiabetic property especially of root, stem and leaf extract. Plant produces several phytochemicals responsible for antidiabetic activity. Four proteins were selected based on literature survey and retrieved from protein data bank. The 18 chemicals were converted into 3 D structure and docked with diabetic protein. Benzeneacetonitrile, .Alpha.-(.Beta.-D-Glucopyranosyloxy)-, (R)- is a chemical expressed in salacia which showed good antidiabetic property among 18 other chemicals. Benzeneacetonitrile, .Alpha.-(.Beta.-D-Glucopyranosyloxy)-, (R)- inhibit the diabetic causing proteins and regulate the glucose level in animal system. This study will helpful in future for developing a novel drug to treat diabetes by using advance in silico tools


Keywords: In silico, Diabetic, Phytochemicals and Benzeneacetonitrile, .Alpha.-(.Beta.-D-Glucopyranosyloxy)-, (R)

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How to cite this article:

Ramakrishna, D., A.T. Shashank, S. Kiran, K.M. Kumar and Ravishankar, G.A. 2018. In silico Identification of Inhibitors from Salacia reticulata Plant against Diabetic Target Protein.Int.J.Curr.Microbiol.App.Sci. 7(1): 431-438. doi: https://doi.org/10.20546/ijcmas.2018.701.050
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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