National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
One important class of anti-pseudomonal drug is the Fluoroquinolones (FQ) which is also available in oral form, in most countries. However, P. aeruginosa easily becomes resistant to FQs, which severely limits its usefulness. We carried out an antibiogram analysis of five FQs viz. Ciprofloxacin, Ofloxacin, Levofloxacin, Prulifloxacin and Moxifloxacin on 80 P. aeruginosa clinical isolates. This prospective study was carried out in the Department of Microbiology of a tertiary care teaching hospital in southern Rajasthan. For the same, 80 non-repetitive P. aeruginosa isolates, obtained from various clinical samples were assed for resistance to five Fluoroquinolones (FQs) by using Kirby-Bauer disc diffusion method. The resistance patterns were noted and statically analyzed to find any significance. A significant resistance (p <0.05) was noted towards Ciprofloxacin, Ofloxacin, Levofloxacin in the P. aeruginosa isolates obtained from out-patients (OPD) when compared to intensive care unit (ICUs). On the other hand, significant resistance (p<0.05) for Ofloxacin, Prulifloxacin and Moxifloxacin was obtained for the isolates from wards when compared to the ICU. The overall resistance rates of Ciprofloxacin, Ofloxacin and Levofloxacin were significantly higher than those to Prulifloxacin (p=0.000). Also Moxifloxacin was significantly resistant when compared to all other FQs tested (p=0.000). The resistance to FQs was more in the OPDs when compared to the ICUs, while Moxifloxacin had the highest resistance rates. The probable causes for this may relate to previous exposure to FQs.
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