Septicemia in neonates refers to generalized bacterial infection documented by positive blood culture in the first four weeks of life. Neonatal sepsis is one of the commonest causes of neonatal mortality in the developing world. To isolate and identify the bacterial isolates responsible for neonatal sepsis. Objective of the study is to determine the susceptibility pattern of isolates. 80 blood samples were collected and processed from patients in accordance with standard protocols. Identification of organisms, the antibiotic susceptibility of the isolates and Methicillin resistant Staphylococcus aureus (MRSA) and ESBL detection was done by Kirby Bauer disc diffusion method according to National Committee for Clinical Laboratory Standards (NCCLS) recommendations. Among the culture positive specimens, Klebsiella pneumoniae was the most commonly isolated pathogen followed by Escherichia coli and overall Gram negative organisms were isolated predominantly than gram positive organisms Gram negative bacteria also exhibited high resistance to the commonly prescribed group of drugs such as penicillins and cephalosporins, Klebsiella pneumoniae and MRSA were the commonly isolated gram negative and gram positive organism respectively.

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