National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Accurate diagnostic tests have important role to play in the management of patient and the control of Tuberculosis (TB) infection. Direct microscopy method of diagnosing TB is very common in areas with high prevalence of tuberculosis but the current quest for automated liquid culture like BACTEC Mycobacterium Growth Indicator Tubes (MGIT) 960 has challenge the relevance of direct microscopy. This study aimed to compare direct microscopy and BACTEC MGIT 960 using Lowenstein Jensen culture medium (LJ) as the reference standard. 340 participants were recruited into the study; 192 males and 148 females between the age group 10 to 64 years. Findings shows that BACTEC MGIT 960 has sensitivity and specificity of 100.0% and 56.4% respectively, and a negative predictive value of 100.0% when compared with the reference standard indicating the proportion of AFB negative participants were actually not infected with M. tuberculosis the above test result was compare with the test result from direct microscopy and was statistically significant (P=0.001), indicating that the conventional method is comparable with MGIT. Of the 340 positive sputa by MGIT, 102 specimens were contaminants representing 30% contamination rate. Expensive equipments like BACTEC MGIT 960 for laboratory diagnosis of MTB could be replaced with direct sputum microscopy especially in resource constrain settings.
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