National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Vaccination plays an important role in the successful control of infectious bursal disease (IBD). Despite the regular use of IBD vaccines, the disease prevails in Haryana state and affects the flocks of different age groups. Control of IBD poses one of the most challenging tasks in the poultry health management. To evaluate the vaccine immune response of IBD vaccines, an experimental study was conducted using two commercial intermediate plus vaccines P and Q. The level of maternal antibodies (MAbs) ranged from 6834.6 to 9925.60 in day old chicks. In experimental birds the age of vaccination was calculated on the basis of MAb titres and it came to be 17 days of age. The mean maternal antibody titre of chicks at 1, 7 and 14 day age was 7874.21, 2449.4 and 1089.9. The mean MAb titre showed a steady decline in the titre from day old age to 14th day of age. Vaccine P showed static increase in ELISA antibody titres from 7 DPV however vaccine Q showed quite higher level of antibody titres on 7 DPV itself which remain protective till the end of experiment in both. CD4+ cells increased at 7 DPV, decreased at 14 and 21 DPV, again increased at 28 DPV. CD8+ cells increased at 7 DPV, decreased at 14 DPV, again increased at 21 and 28 DPV. This decrease in CD4+ and CD8+ cells at 14 and 21 DPV is probably due immunosuppressive effect of IBD vaccines. Both vaccines P and Q provided protective immunity from 7 DPV till the end of experiment but with immunosuppressive effect of IBD vaccines. Further studies are required to see the variation in protection and to monitor immunosuppression induced by different vaccine strain available in our area.
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