Oral cavity is said to be the mirror of systemic health. It has long been known, that many systemic diseases first manifest in the oral cavity. On the other hand oral diseases have a potential to act as an independent risk factor for causing systemic disease. Currently, this bidirectional view is quickly gaining acceptance, due to significant findings supporting the association between periodontal disease and systemic conditions such as CVD, T2DM, adverse pregnancy outcomes, osteoporosis, Metabolic Syndrome. Significant effort has brought numerous advances in revealing the etiological and pathological links between this chronic inflammatory dental disease and these other conditions. The role of microorganisms in the causation and pathogenesis of periodontal disease is well documented. Within the past 10 years, many studies have been published indicating a positive or negative relationship between periodontitis and various systemic diseases, including Met.S. The most frequently identified periodontal pathogens include three microaerophilic species (A. actinomyctemcomitans, Campylobacter rectus, and Eikenella corrodens). The results of the present study confirmed increased colonization of periodontal pathogen, A. actinomyctemcomitans in both periodontitis patients without Met.S and Periodontitis patients with Met.S.

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