National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Enteric fever is an important public health problem in India and accounts for high morbidity and mortality. Specific antibiotic therapy is the mainstay of management of enteric fever. Emergence of multi drug resistant Salmonella isolates has led to the need of continuous monitoring of susceptibility pattern to these agents. Hence this study was conducted to detect minimum inhibitory concentrations of ciprofloxacin, ceftriaxone and azithromycin among enteric fever isolates and to formulate an antibiotic policy. A prospective study was conducted for three years duration among enteric fever isolates. Susceptibility was determined phenotypically by disk diffusion testing and MIC by E-strip testing. Total of 62 Salmonella isolates from blood samples of enteric fever patients were studied. Salmonella paratyphi A isolates outnumbered Salmonella typhi isolates. Ciprofloxacin resistance was observed among 16 (25.8%) isolates with MIC of ≥1 μg/mL. MIC estimation was better predictor of resistance in vivo as compared to disk diffusion testing. We observed rising MIC to ceftriaxone and azithromycin. As MIC is superior to disk diffusion testing in predicting the clinical outcome, susceptibility reporting should depend on MIC results, if facilities are available to prevent treatment failures.
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