National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Toxicity of zinc chloride on Swiss albino mice of either sex was determined. Graphical method as described by Miller and Tainter was used for the determination of accurate value of LD50. Five groups of mice of either sex containing ten animals in each group were selected for the experiment. Five doses of zinc chloride which were near to the approximate LD50 viz., 1000, 1100, 1200, 1300 and 1400 mg/kg b. wt. were chosen and given orally. The animals were observed for 2 hour and then at 4, 6, 24, 72, and 96 hour for any toxic signs and symptoms. After 96 hour the number of deceased mice in each group was counted and % mortality were calculated. LD50 of zinc chloride was found to be 1230 mg/kg b.wt. The Standard error (SE) of the LD50 was calculated using the formula: Approx. SE of LD50 = (Log LD84 - Log LD16) / 2N, and found to be 129.69. Thus LD50 of zinc chloride (ZnCl2) by oral route in Swiss albino mice was found
to be 1230 ± 129.69 with 95% confidence level.
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