National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Vitamins are essential for various biological responses in the human body and various researches indicated its role in immunity. With water soluble vitamins, B complex is being the most commonly prescribed supplements in clinical practice. This study was undertaken to find out in vitro effect of water soluble vitamin B complex against antibiotics commonly prescribed for respiratory infections caused by Klebsiella pneumoniae. 50 isolates of Klebsiella pneumoniae were isolated from sputum samples and their antibiotic sensitivity patterns were performed. 10 μl of commercially available solutions of Vitamin B complex were added along with antibiotics and incubated. The sensitivity pattern and zone diameters of antibiotics along with vitamins were recorded. The differences in zones were statistically analysed by student t test for significance. Out of 50 isolates of Klebsiella pneumoniae included in the study, there were six ESBL (Extended spectrum beta lactamase) producers. Vitamin B complex significantly enhanced the antibacterial activity of Imipenem, Piperacillin-tazobactam and decreased the antibacterial activity of Chloramphenicol in vitro. There exist significant interactions between water soluble Vitamin B complex and antibiotics in vitro as noted by Kirby-Bauer disc diffusion methods. This study can also be extended to research with multidrug resistant organisms.
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