National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The pharmacokinetic of meloxicam (5 mg/kg) and effect of co-administration of andrographolide (50 mg/kg) on pharmacokinetics of meloxicam were studied following intramuscular administration in rats. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC). The mean peak plasma drug concentration of 30.48  1.44 mg/mL was achieved at 0.25 h. The pharmacokinetic parameters like mean absorption half-life (t½α) (9.71  0.3 h), elimination half-life (t½β) (12.14  0.006 h), apparent volume of distribution (Vdarea) (0.23  0.006 L/kg), area under plasma drug concentration-time curve (AUC0-∞) (383.85  8.68 ïÂÂg.h/mL), area under first moment curve (AUMC) (8813.72  145.23 ïÂÂg.h2/mL), total body clearance (ClB) (0.01  0.001 L/h/kg) and mean residence time (MRT) (22.63  0.36 h) were observed. Following co-administration of andrographolide with meloxicam after single intramuscular administration in rats, the mean peak plasma concentration of meloxicam was significantly decreased. The pharmacokinetic parameters like absorption half-life (t½Ka) and AUC0-ï‚¥were significantly increased whereas elimination half-life, Cmax and Vd were significantly decreased. This pharmacokinetic interaction might be due to drug-drug interactions.
Citations |
 |
 |
 |
 |
