National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
In several published studies, viruses have been implicated in the pathogenesis of breast cancers. Human Herpes virus 8 (HHV-8) has recently emerged as causal factors of human breast cancers. This study aims to assess the prevalence of HHV-8 DNA in women with breast cancer. HHV-8 DNA was detected using Real-Time PCR in EDTA-treated whole blood samples obtained from 45 breast cancer patients in Suez Canal University Hospital. HHV-8 DNA was detected in 13(28.8%) patients. The prevalence of HHV-8 increased with increasing tumor grade (0% for grade I, 50% and 100% for grades II and III, respectively). The prevalence of HHV-8 DNA was higher (12 out of 12; 100%) in patients with lymph node (LN) metastasis compared lymph node-negative patients (1 out of 33; 3 %). The prevalence of HHV-8 infection increased significantly with increasing tumor grade and LN metastasis suggesting that HHV-8 may be a contributing factor to breast cancer progression and metastasis.
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