International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:5, May, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(5): 75-83

Synthesis of Some Sulfa Drug Derivatives as Antibacterial Agents
Salman A. Ali1, Anmar H. Jabbir1* and Rana A. Mohsie2
1Department of Chemistry, Faculty of Science, Al-Nahrain University, Baghdad, Iraq
2College of Applied Biotechnology, Al-Nahrain University, Baghdad, Iraq
*Corresponding author

Sulfa drugs are an important class of synthetic bacteriostatic antibiotics still used today for the treatment of bacterial infections and those caused by other microorganisms, sulfa drugs achieve this bacteriostatic action by inhibiting the synthesis of folic acid in bacteria. The current study has the aim of Synthesis of some of sulfa drug compounds and Study the biological activity of the synthesized compounds against two types of bacteria: Staphylococcus aureus (Gram positive) and Pseudomonas aeruginosa (Gram negative).These compounds were formed successfully by chlorosulfonation of acetanilide and the product was treated with different amines and finally amide hydrolysis was necessary to get agents that were analyzed for IR, UV and melting points. At last, we studied their antibacterial activity on certain types of bacteria. We carried out an antibacterial evaluation in vitro of a series of five synthetic sulfa drugs (IIIa, IIIb, IIIc, IIId and IIIe) and from the results, antibacterial activity studies indicate that halo substituted sulfonamide (compound IIIc) was more active than the other members.

Keywords: Sulfa drugs, Staphylococcus aureus, Pseudomonas aeruginosa, chlorosulfonation, IR, UV.

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How to cite this article:

Salman A. Ali, Anmar H. Jabbir and Rana A. Mohsie. 2016. Synthesis of Some Sulfa Drug Derivatives as Antibacterial AgentsInt.J.Curr.Microbiol.App.Sci. 5(5): 75-83. doi:
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