National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Sulfa drugs are an important class of synthetic bacteriostatic antibiotics still used today for the treatment of bacterial infections and those caused by other microorganisms, sulfa drugs achieve this bacteriostatic action by inhibiting the synthesis of folic acid in bacteria. The current study has the aim of Synthesis of some of sulfa drug compounds and Study the biological activity of the synthesized compounds against two types of bacteria: Staphylococcus aureus (Gram positive) and Pseudomonas aeruginosa (Gram negative).These compounds were formed successfully by chlorosulfonation of acetanilide and the product was treated with different amines and finally amide hydrolysis was necessary to get agents that were analyzed for IR, UV and melting points. At last, we studied their antibacterial activity on certain types of bacteria. We carried out an antibacterial evaluation in vitro of a series of five synthetic sulfa drugs (IIIa, IIIb, IIIc, IIId and IIIe) and from the results, antibacterial activity studies indicate that halo substituted sulfonamide (compound IIIc) was more active than the other members.
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