International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:4, April, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(4): 929-934

Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus in a Tertiary Care Centre, Kerala, India
I.R. Regha*, Deepa Harichandran and B. Sulekha
Department of Microbiology , Sree Narayana Institute of Medical Sciences,Chalakka, Ernakulam, Kerala, India
*Corresponding author

Drug resistance among Staphylococcus aureus is an increasing problem. Clindamycin is one of the  effective antibiotic for treating  both methicillin sensitive and resistant Staphylococcal infections. A major concern regarding the use of clindamycin therapy is the presence of inducible resistance. In vitro routine tests for clindamycin susceptibility may fail to detect inducible resistance resulting in treatment failure. The present study aimed to find out the  inducible clindamycin resistance in the clinical isolates of Staphylococcus aureus  using D test.  The study was conducted at the Department of Microbiology in Sree Narayana Institute of Medical Sciences, Kerala over a period of one year. All of the total 220 S.aureus  isolates  during the  period were included in the study. D test was done in the erythromycin resistant strains as per CLSI guidelines. Inducible clindamycin resistance was observed in 12.7%, constitutive resistance in 8.1% and MS phenotype in 41.8% of the total isolates. The rate of MRSA and MSSA were  41.8% and 58.2% respectively. Inducible resistance and constitutive resistance were higer in MRSA (34.8% and 10.9%  respectively) as compared to MSSA where the inducible resistance was only 3.1% and  no constitutive resistance was noticed. 19.6% of MRSA and 21.9% of MSSA showed MS phenotype. Inducible clindamycin resistance was more common than constitutive  resistance  in our hospital. Both inducible and constitutive resistance showed higher incidence among MRSA than MSSA. The trends in resistance may vary from place to place. So D- test should be done routinely to delineate different  resistant phenotypes in the laboratory to help clinicians for  the judicious use of clindamycin in order to avoid therapeutic failure  as well as irrational use of higher antibiotics.

Keywords: Clindamycin,D test, MLSB phenotype, Staphylococcus aureus.

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How to cite this article:

Regha, I. R., Deepa Harichandran and Sulekha, B. 2016. Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus in a Tertiary Care Centre, Kerala, India.Int.J.Curr.Microbiol.App.Sci. 5(4): 929-934. doi:
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