National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
A study was carried out to evaluate the hepatoprotective property of Alternanthera sessilis in CCl4 induced hepatotoxicity in rats. A total of 36 Wister rats were selected for the purpose of study, segregated into six different groups having six numbers of animals in each. Group T1 was kept as negative control and fed standard basal diet for a period of four weeks. Group T2 was kept as positive control and subjected to CCl4 plus liquid paraffin (50% v/v) treatment at the rate of 2ml/kg body weight twice a week for three weeks. Group T3 was treated with Silymarin at 100 mg/kg body weight concurrently with CCl4 toxicity for four weeks. Group T4, T5 and T6 were treated with aqueous extract of Alternanthera sessilis at 100 mg/kg body weight, 300 mg/kg body weight and 900 mg/kg body weight respectively and concomitantly with CCl4 toxicity. Results revealed that there was significant decrease in the various hepatic biomarkers viz. ALT, ALP, AST in the aqueous extract of Alternanthera sessilis treated groups T4, T5 and T6 as compared to positive control group T2. Histopathological examination also revealed that the hepatic damage wrought by CCl4 toxicity was significantly thwarted in the aqueous extract of Alternanthera sessilis treated groups. Thus it can be inferred that aqueous extract of Alternanthera sessilis can significantly ameliorate signs of hepatotoxicity in the CCl4 induced hepatotoxic rats.
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