National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Extended spectrum beta lactamase producers are posing a major obstacle in the therapeutic outcome of patients. They cause enzymatic hydrolysis of the beta lactum ring, resulting in resistance to penicillins and cephalosporins. The rise in ESBL producers results in prolonged treatment which leads to increased hospital stay and financial burden on the patient. It is necessary for all the hospitals to monitor ESBL producers to formulate preventive and therapeutic measures accordingly. The study was conducted in a tertiary care hospital during the period from December 2015 to November 2016. A total of 500 isolates from Enterobacteriaceae which included 400 Escherichia coli and 100 Klebsiella species isolates were processed. ESBL producers were detected by phenotypic screening and confirmatory methods which included double disc synergy method, Cephalosporin Clavulanate combination disc. Out of 400 Escherichia coli, 220 were ESBL producers (55%) and 34 out of Klebsiella species were ESBL producers (34%). Overall ESBL production was 50.8% and it was found to be higher in inpatients (55.67%) than outpatients (41.28%). All ESBL producers are 100% susceptible to Imipenem and Meropenem and maximum resistance to penicillin and cephalosporins (80-90%). ESBL producers pose threat in hospitals; their detection can be made mandatory along with routine antibiogram.
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