National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
In this report, an attempt to study the effect of production of inhibitory bioactive compounds and fiber hydrolytic enzymes was demonstrated by mutagenic agent treatment analysis. The effects of two chemical mutagenic agents [N-methyl-N'-nitro-N-nitrosoguanidine (NTG) (65-500 µg/ml) and Ethidium Bromide (EB) (5-25 µM)] on the loss of enzymes and antibiotic activities and generation of bald mutants (no aerial mycelia) in Streptomyces strain N-404, were observed. Generation of bald mutants was observed with treatment with 65 µg/ml of NTG and 10 µM EB after 5 and 14 days, respectively. Production of antibiotics and fiber hydrolytic enzymes (amylase, cellulase, and xylanase) was not eliminated, but noticeable reduction of these activities in the mutant strain was detected.
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