National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present study was performed in order to investigate the antiulcer activity of different extracts of the root of Morinda citrifolia Linn (Rubiaceae) using different models of gastric and duodenal ulceration in rats. Gastric ulcers were induced by oral administration of ethanol, aspirin and by pyloric ligation while the duodenal ulcers were induced by oral administration of cysteamine hydrochloride. The extracts were administered at a dose of 200 and 400 mg/kg orally 30 minutes prior to ulcer induction. Ranitidine (50 mg/kg) was used as a reference standard. The antiulcer activity was accessed by determining and comparing the ulcer index in the test group with that of the standard drug treated group. Gastric volume, total acid and free acid were estimated in the pylorus-ligated rats. M. citrifolia (400 mg/kg) showed maximum inhibition of gastric acid, free acid and total acid to 52.23%, 55.23% and 29.11% respectively. The ulcer index in the M. citrifolia treated animals was found to be significantly less in all the models compared to standard drug treated cases. The antiulcer activity of extracts was however less than that of standard drug ranitidine. The results suggest that the roots of M. citrifolia possesses significant antiulcer property which could be due to cytoprotective action of the drug or strengthening of gastric and duodenal mucosa with the enhancement of mucosal defense.
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