International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:4, April, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(4): 91-100

Pathological Study of Oral Squamous Cell Carcinoma by Application of P53 and PCNA (Immunohistochemical Approach)
Susan N.Abdulkadir1*, Najat R.Ali2, and Najwa J. Alchalabi3
1Azadi teaching hospital, Iraq
2Collage of Dentistry, Kirkuk University, Iraq
3Bagdad Medical City, Iraq
*Corresponding author

Carcinogenesis is a multi-step process involving the activation of oncogenes and inactivation of tumor suppressor genes. Tumor cell growth results from disturbance in the balance between the rate of proliferation and cell death apoptosis. Apoptosis is an active process of cell destruction that requires the activation of a genetic program that may lead to changes in cell morphology, DNA fragmentation, and protein cross-linking. The mechanism of apoptosis provides protection from the possible consequences of uncontrolled cell proliferation which could lead to neoplasia. The aim of this study was to determine the immunohistochemical expression of the P53 and PCNA in oral squamous cell carcinoma. Twenty specimen of oral squamous cell carcinoma were selected for analyses by using the Avidin-biotin complex (ABC) detection system with antibodies against P53 and PCNA it was observed positive labeling for P53 in 19 cases (95%) and one case (5%) was negative and for PCNA however there was a positive labeling in 19 cases (95%) while one case (5%) was negative. It was concluded that distribution of immune reactivity for P53 was observed to be similar to that of PCNA. There appears to be a relationship between P53 and PCNA expression with all malignancy grading. Expression of P53 and PCNA at oral SCC has a prognostic significance. PCNA expressions have been associated with biologically aggressive tumors. PCNA is a good indicator for detecting malignant potentiality in all grades OSCC.

Keywords: Oral Squamous Cell Carcinoma, PCNA,Immuno-histochemical.

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How to cite this article:

Susan N. Abdulkadir, Najat R. Ali, and Najwa J. Alchalabi. 2016. Pathological Study of Oral Squamous Cell Carcinoma by Application of P53 and PCNA (Immunohistochemical Approach).Int.J.Curr.Microbiol.App.Sci. 5(4): 91-100. doi:
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