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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Hepatitis B virus (HBV) impacts large number of populations worldwide and has both hepatic and extrahepatic manifestations. It can present as acute hepatitis, chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC). The available data provide evidence that HBV infection is associated with the risk of developing HCC with or without an underlying liver cirrhosis, due to various direct and indirect mechanisms promoting hepatocarcinogenesis. We report a twenty-three-year-old male, not a known case of any chronic illness presented with distension of abdomen. On evaluation he was diagnosed to be having hepatitis B related cirrhosis of liver with hepatocellular carcinoma with portal vein thrombosis. His ultrasonogram showed altered echotexture of liver with suspicious lesions in both lobes of liver with ascites and portal vein thrombosis. On subjecting to Triple phase Computed tomography scan confirmed ultrasonography findings and suspicious lesions showed enhancement on arterial phase and wash out on venous and portal phase. His liver function tests were deranged, Alpha feto protein level (AFP) was significantly raised to 1050 I.U. and HBV DNA quantitative was one lakh I.U/ml. He was unmarried and on family screening his mother was found to be chronic hepatitis B but in inactive carrier stage. Hepatitis B has many presentations varying from inactive carrier stage in majority to cirrhosis and H.C.C but presenting for first time with H.C.C in such a young age is not common, thus making treating health professionals for becoming more vigil for such deadly and acute catastrophic face of Hepatitis B.
Abraham P. Viral Hepatitis in India. Clin Lab Med. 2012;32(2):159–174. https://doi.org/10.1016/j.cll.2012.03.003
Bosch F X, Ribes J, Cleries R, Diaz M. Epidemiology of hepatocellular carcinoma. Clin Liver Dis 2005; 9:191–211. https://doi.org/10.1016/j.cld.2004.12.009
Cohen C, Holmberg S D, McMahon B J, Block J M, Brosgart C L, Gish R G et al., Is chronic hepatitis B being undertreated in the United States? J Viral Hepat. 2011 Jun;18(6): 377-83. https://doi.org/10.1111/j.1365-2893.2010.01401.x
Dutta S. An overview of molecular epidemiology of hepatitis B virus (HBV) in India. Virol J. 2008; 5:156. https://doi.org/10.1186/1743-422x-5-156
El-Serag H B, Rudolph K L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132:2557–2576. https://doi.org/10.1053/j.gastro.2007.04.061
El-Serag H B. Hepatocellular carcinoma. N Engl J Med 2011; 365:1118–1127. https://doi.org/10.1056/nejmra1001683
Ferlay J, Soerjomataram I, Dikshit R, et al., Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136(5): E359-86. http://dx.doi.org/10.1002/ijc.29210 (PMID: 25220842)
Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018;391(10127):1301-1314. https://doi.org/10.1016/s0140-6736(18)30010-2
Konyn P, Ahmed A, Kim D. Current epidemiology in hepatocellular carcinoma. Expert Rev Gastroenterol Hepatol. 2021;15(11):1295-1307. https://doi.org/10.1080/17474124.2021.1991792
Massarweh N N, El-Serag H B. Epidemiology of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. Cancer Control. 2017;24(3):1073274817729245. https://doi.org/10.1177/1073274817729245
Rizzo G E M, Cabibbo G, Craxì A. Hepatitis B Virus-Associated Hepatocellular Carcinoma. Viruses. 2022 May 7;14(5):986. https://doi.org/10.3390/v14050986. PMID: 35632728; PMCID: PMC9146458
Sarin S K, Dhiman R K, Eapen C A, et al., Technical Guidelines for Diagnosis & management of Hepatitis 2019; National Viral Hepatitis Control Program, India.
Sayiner M, Golabi P, Younossi Z M. Disease burden of hepatocellular carcinoma: a global perspective. Dig Dis Sci. 2019;64(4):910-917. https://doi.org/10.1007/s10620-019-05537-2
Stanaway J D, Flaxman A D, Naghavi M, et al., The global burden of viral hepatitis from 1990 to 2013: Findings from the global burden of disease study 2013. Lancet 2016; 388(10049): 1081-8. http://dx.doi.org/10.1016/S0140-6736(16)30579-7 (PMID: 27394647)
Thyagarajan S P, Jayaram S, Mohana Valli B. Prevalence of HBV in general population in India. In: Sarin SK, Singal AK, Editors. Hepatitis B in India: problems and prevention. New Delhi: CBS; 1996. p. 5–16.
World Health Organisation. Global Hepatitis Report. 2017
Yang J D, Roberts L R. Hepatocellular carcinoma: A global view. Nat Rev Gastroenterol Hepatol 2010; 7(8): 448-58. http://dx.doi.org/10.1038/nrgastro.2010.100 (PMID: 20628345)
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