National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present study was carried out to determine the adverse effects of fluoride on the rat gastric mucosa. Twelve albino rats were used. The experimental group was treated with 600 mg/kg b.w./day of sodium fluoride for 40 days via oral gavage. The control group had distilled water for the same period. The rat stomachs were prepared for light microscopic, scanning and transmission electron microscopy. The pathological and ultrastructural changes include loss of surface epithelium, microvilli and structural integrity, along with extensive cell degeneration and mucosal erosion indicating that sodium fluoride has a severe detrimental impact on the gastric tissue, compromising both its protective and functional capabilities.
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